Fadogia Agrestis
Fadogia Agrestis is a Nigerian shrub extract that Huberman uses for testosterone support. Unlike Tongkat Ali, Fadogia may directly stimulate testosterone production.
How Fadogia Works
Fadogia appears to work at the testicular level:
- Acts on Leydig cells in the testes
- May increase luteinizing hormone (LH) sensitivity
- Stimulates testosterone production directly
- Different mechanism than SHBG-reducing compounds
Typical Dosage
| Timing | Dose | Notes |
|---|---|---|
| Morning | 300-600mg | With food |
Critical: Cycling Required
Fadogia should be cycled on and off.
| Schedule | Protocol |
|---|---|
| Conservative | 8 weeks on, 2-4 weeks off |
| Aggressive | 12 weeks on, 4 weeks off |
Continuous use without cycling is not recommended due to limited long-term safety data.
Why Cycling Matters
- Prevents potential testicular toxicity
- Allows natural hormone feedback to reset
- Long-term human safety data is limited
- Huberman emphasizes this cycling requirement
Stack with Tongkat Ali
Often combined for synergistic effect:
| Substance | Mechanism |
|---|---|
| Tongkat Ali | Frees testosterone (SHBG reduction) |
| Fadogia | Stimulates production (Leydig cells) |
The combination addresses both production and availability.
Cautions
⚠️ Limited human research. Most studies are in animals.
| Concern | Recommendation |
|---|---|
| Testicular effects | Cycle on/off |
| Long-term safety | Unknown in humans |
| Quality control | Use reputable brands |
| Individual response | Monitor how you feel |
Get baseline blood work before starting and periodically while using.
Who Benefits Most
- Men seeking natural testosterone support
- Those already optimizing other lifestyle factors
- People who tolerate Tongkat Ali and want to add to stack
- Athletes in natural competition
Who Should Avoid
- Women (not studied)
- Anyone with hormone-sensitive conditions
- Those unwilling to cycle properly
- People not monitoring blood work
Related Pages
“You need to cycle Fadogia Agrestis. Don’t take it continuously.” — Andrew Huberman